Nodular sclerosis (NS) The affected lymph node has nodules of normal lymphocytes and other "reactive" cells , together with Reed-Sternberg cells, separated by bands of scar-like tissue . This is the most common type of HD and is the only type more common in women than in men. It is usually found as a limited-stage disease involving the lymph nodes of the lower neck, above the collarbones and within the chest in adolescents and young adults. This type is unusual in people over age 50.
Lymphocyte predominant (LP) The affected lymph nodes are composed largely of reactive lymphocytes. The malignant cells have a "popcorn" appearance, distinct from Reed-Sternberg cells (which are rare in this sub-type). The cells may be arrayed in a nodular or diffuse pattern. This type is most common in people under 35 and affects men more frequently than women. The disease is most often in limited stage when it is discovered and patients rarely have symptoms at the time of diagnosis. Recent information has linked the nodular variety to the B cell of the immune system , similar to most non-Hodgkin's lymphomas. Some pathologists and clinicians feel this sub-type should be reclassified as a non-Hodgkin's lymphoma; however, others disagree.
Mixed cellularity (MC) The affected lymph node contains a mixture of inflammatory cells in addition to abundant Reed-Sternberg cells. Adults with this type are often older and have widespread disease at the time of diagnosis.
